New antibody drug to boost COVID fight

Q: How will the new therapy help the fight against COVID-19?

Zhang: The antibody therapy is mainly used to treat patients with mild or moderate symptoms and those at a high risk of developing severe symptoms, including patients with severe underlying health problems such as diabetes and cardiovascular diseases. It can reduce the rate of hospitalization and death by 80 percent.

The antibody drug not only prevents the virus from penetrating cells, but also boosts our immunity because the antibody itself is part of our immune system.

The antibody drug is immediately effective once administered intravenously. It can stay alive in the human body for nine to 12 months. So it has great potential in preventing infection.

It is especially useful for high-risk groups, such as frontline medical workers and people not suitable for vaccination due to weak immune systems, liver and kidney problems and underlying health problems.

Q: Will we gain more market approvals beyond China to make greater contribution to the global battle against COVID-19?

Zhang: We're not only aiming at serving Chinese people but also people around the world. It is an international cooperation project.

After entering the phase one clinical trial in China, we conducted phase two and phase three clinical trials in areas with high COVID-19 prevalence as the epidemic had been basically brought under control in China.

We participated in a global trial program sponsored by the US National Institutes of Health. And we earned a high score among global competitors.

So we were able to conduct phase two and phase three clinical trials in 111 clinical trial sites in six countries.

Trial data found the therapy could reduce the rate of hospitalization and death of high-risk patients by about 80 percent.

On Dec 8, we were granted emergency approval by China's National Medical Products Administration.

At the same time, we have contacted the US Food and Drug Administration. We expect to gain US' FDA approval in the near future.

Many countries have already contacted us and expressed their wishes to use our therapy.

Q: When will the new antibody drug hit the market?

We are pushing for the market launch as early as possible. But several procedures are needed.

A treatment guideline must be formulated. The conditions for storage, shipping and production must also be met. This process may take a few days or a few weeks.

It takes about two to three months to finish production after we receive an order. So we are also pushing for a mechanism like pre-purchase or reserve.